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18β-GA inhibits the activation of NFATc1 on osteoclastogenesis. (A) 18β-GA suppresses the binding of RANK and TRAF6. (B) 18β-GA had no significant effects on the expression of c-Fms mediated by M-CSF. However, the RANK expression was decreased by 18β-GA. (C) 18β-GA inhibits the mRNA levels of NFATc1. (D) 18β-GA inhibits osteoclastogenesis through NF-κB pathway and MAPK pathway of RANKL signaling.
