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. 2018 Jun 20;9:647. doi: 10.3389/fphar.2018.00647

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Copyright © 2018 Chen, Zhi, Yin, Li, Qin, Qiu and Su.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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18β-GA ameliorates ovariectomy-induced bone loss in vivo. (A) Representative HE staining of distal femoral sections and quantification of trabecular area from each group 6 weeks after the operation. (B) Micro CT analysis of the distal femur from sham, OVX, and OVX + 18β-GA group. (C) Calculations of trabecular number (Tb.N), bone mineral density (BMD), bone surface area/total value (BS/TV) and bone value/total value (BV/TV). (D) Representative TRAP-stained histologic distal femur sections from sham, OVX and OVX + 18β-GA group. (E) Serum IL-6, TNF-α, TRAcp5b, and CTX-1 were examined. (F) Calcein double labeling with a 7-day interval (Scale bar: 100 μm). Mineral apposition rate (MAR) is significantly decreased in OVX mice and reversed by 18β-GA (^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001).