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. 2018 Jun 20;9:459. doi: 10.3389/fneur.2018.00459

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Copyright © 2018 Mehta, Awah and Sonabend.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) In a recent study, we found that mice treated with 80 μM etoposide via Convection Enhanced Delivery (CED) demonstrated prolonged survival when compared control mice treated with 4 μM (the mean concentration achieved in previous studies using etoposide). Additionally, mice treated with 680 μM had a significant survival benefit when compared to control mice, with a 75% cure rate. (B) Graphic illustrating different doses of etoposide delivered in this study; 4 μM, 80 μM, 680 μM. (C) Mice treated with 680 μM of etoposide using CED also demonstrated lower bioluminescence signal, measured by using bioluminescence imaging to monitor luciferase signaling. Figures reproduced with permission from Oxford University Press.