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. 2018 Jun 20;12:332. doi: 10.3389/fnins.2018.00332

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Copyright © 2018 Iacobas, Iacobas, Nebieridze, Velíšek and Velíšková.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The transcriptomic networks by which the estrogen-signaling (ESG) pathway genes regulate the glutamatergic synapse (GLU) genes through expression coordination with the common genes (CG) between the two pathways in OVX rats with E2-replacement. (A) Networks in the DG of non-SE animals. A red/blue line indicates that the linked genes are significantly (p-value < 0.05) synergistically/antagonistically expressed, respectively. Numbers on the left side represent the percentages of the synergistically (S)/antagonistically (A)/independently (I) expressed pairs that can be formed between the two groups of genes. (B) Networks in the DG of SE animals. Red/green/yellow background of the gene symbol indicates that that gene was up-/down-/not regulated by SE. Note that there is a substantial shift from synergistic to antagonistic expression between ESG and CG groups in SE animals.