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The transcriptomic networks by which the estrogen-signaling (ESG) pathway genes regulate the cholinergic synapse (ACH) genes through expression coordination with the common genes (CG) between the two pathways in OVX rats with E2-replacement. (A) Networks in the DG of non-SE animals. (B) Networks in the DG of SE animals. Note the substantial shift from synergistic to antagonistic expression between ESG and CG groups in SE animals.
