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TMAO improves behavioral phenotypes of tau-expressing worms. (A) Mock-Tg or WT4R(H)-Tg worms were treated with TMAO for 4 days and evaluated for Unc. The data indicate the populations of severely affected worms (means ± SEM, n = 5). (B) Total lysates from TMAO treated worms were analyzed by Western blotting using antibodies indicated. (C) The amounts of tau and α-tubulin were quantified (means ± SEM, n = 7). Statistical significance was analyzed by Tukey’s post hoc test (∗p < 0.05).
