Table 1.

HDAC classes and their inhibitors.

HDAC Class	Member	Subcellular Localization	Tissue Distribution	Inhibitors
Class I	HDAC 1	Nucleus	Ubiquitous	SAHA, TSA, Entinostat (MS-275), Crebinostat, Valproic acid, compound 60, Fingolimod, Mocetinostat
	HDAC 2	Nucleus	Ubiquitous	SAHA, TSA, Entinostat (MS-275), Crebinostat, Valproic acid, Compound 60, Fingolimod, Apicidin
	HDAC 3	Nucleus	Ubiquitous	SAHA, TSA, Entinostat (MS-275), Crebinostat, Valproic acid, Fingolimod, Apicidin,
	HDAC 8	Nucleus, Cytoplasm	Mostly Ubiquitous	Valproic acid, Fingolimod, NBM-T-L-BMX-OS01
Class IIa	HDAC 4	Nucleus, Cytoplasm	Brain, Heart, Skeletal Muscle	SAHA, Trichostatin A, Sodium Butyrate, MC1568
	HDAC 5	Nucleus, Cytoplasm	Brain, Heart, Skeletal Muscle	SAHA, 4-Phenylbutyrate
	HDAC 7	Nucleus, Cytoplasm, Mitochondria	Heart, Skeletal Muscle, Placenta	SAHA
	HDAC 9	Nucleus, Cytoplasm	Brain, Skeletal Muscle	SAHA
Class IIb	HDAC 6	Predominantly cytoplasm	Heart, Liver, Placenta, Kidney	SAHA, Crebinostat, Tubacin, Tubastatin A, ACY-738, ACY-775
	HDAC 10	Predominantly cytoplasm	Liver, Kidney, Spleen	Tubastatin A, Bufexamac
Class III	Mammalian sirtuins (SIRT1-7)	Nucleus, Cytoplasm, Mitochondria	Fetal brain>adult brain (except SIRT 2 &5). SIRT4 highly expressed in astrocytes (postnatal brain) & in radial glia (embryonic tissues)	Resveratrol, Suramin, Nicotinamide, SRT1720, SRT3657
Class IV	HDAC 11	Nucleus, Cytoplasm	Brain, Heart, Kidney, Skeletal Muscle	Trichostatin A

SAHA: Vorinostat; Fingolimod: phosphorylated-FTY720; TSA: Trichostatin A

(Volmar and Wahlestedt, 2014; Dokmanovic et al., 2007; de Ruijter et al., 2003)