Table 2.
HDAC inhibitor compounds and their reported IC50 (nM). Hull et al., 2016; Beckers et al., 2007; Selleckchem.com
| HDACi | HDAC1 | HDAC2 | HDAC3 | HDAC8 | HDAC4 | HDAC6 | HDAC7 | HDAC9 | Broad Spectrum |
|---|---|---|---|---|---|---|---|---|---|
| TSA | 2±0 | 3±0 | 4±1 | 456±59 | 6±2 | 3±1 | 5±2 | 6±5 | 1.8 |
| Vorinostat (SAHA) | 68±14; 21±13; 10 | 164±45 | 48±17; 37±11; 20 | 1524±463; 1200±380 | 101±31 | 90±26; 25±6 | 104±35 | 107±21 | 10 |
| Entinostat (MS275) | 181±62; 180±70 | 1155±134 | 2311±803; 740±250; 1700 | 44900±18100 | >10,000 HDAC4, 6, 7, 8, 9 | ||||
| Romidepsin (FK228) | 1.6 ; 36 | 3.9 ; 47 | |||||||
| Mocetinostat (MGCD0103) | 34±17 ; 820±1.4 ; 150 | 34±8 ; 290 | 998±431 ; 620±160 ; 1660 | >10,000 HDAC4, 6, 7, 8, 9; 590 HDAC11; | |||||
| Panobinostat (LBH589) | 3±0 | 3±0 | 4±1 | 12±5 | 61±1 | 14±7 | 3±2 | 5-20 | |
| Belinostat | 41±6 | 125±21 | 30±0 | 216±43 | 115±16 | 82±19 | 67±22 | 128±46 | 27 |
| Apicidin | 0.299 | 120±28 | 43±7 | 575±111 | |||||
| Valproic acid | 171000 ; 400000 | ||||||||
| Dacinostat (LAQ824) | 1.8±0.6 | 3.7±3 | 140±34 | 15±7 | 32 | ||||
| Sodium Butyrate | 175000 ; 300000 | 400000 | 300000 |