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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Arthritis Rheumatol. 2018 May 27;70(7):1030–1041. doi: 10.1002/art.40456

Figure 2. Increased levels of ubiquitin and polyubiquitinated substrates in human knee OA cartilages in situ.

Figure 2

Immunohistochemistry of paraffin embedded sections from grade IV OA and normal human knee articular cartilages employed antibodies specific for ubiquitin (Ub) (A) and K48-linked ubiquitin (K48) (B). Safranin-O, and hematoxylin cell staining are shown at 4× magnification. For IHC, 4× and 10× magnification results are shown, with the third panels from the top showing a boxed area magnified in the panels immediately below. Representative of 12 separate normal and 12 separate OA donors.