(A) Western blots of chondrocyte lysates, with densitometric analysis, revealed decreased PSMD11 in OA grade IV compared to normal donor cells. (B)
PSMD11 mRNA levels were significantly decreased in OA compared to normal chondrocytes (p=0.0008, t-test). (C) Western blots, with densitometric analysis, also revealed decreased p-FOXO4 levels, but no consistent changes in total FOXO4, in OA compared to normal donor chondrocytes.