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. Author manuscript; available in PMC: 2018 Aug 21.
Published in final edited form as: Lab Invest. 2018 Feb 21;98(6):825–838. doi: 10.1038/s41374-018-0026-7

Figure 4. FGF10 affects CFTR-mediated secretion and growth of porcine epithelia.

Figure 4

a–c) In primary pig epithelia cultures, FGF10 increased CFTR mRNA (a) and immunostaining (b,c, bar = 3μm) in non-CF cells (n=3/group) (Control versus combined FGF10 treated groups [24 hr + 72 hr], *P<0.05, Mann Whitney test). Note the example of staining for both groups in (b). d,e) In non-CF and CF primary pig epithelia cultures, FGF10 increased cell height (d) and increased Ki67 index (e) consistent with cellular proliferation (*P<0.05 and **P<0.01, Bonferroni post-test). f,g) Electrophysiology of non-CF and CF (n=3 & 4/group, respectively) primary pig epithelia cultured with FGF10. FGF10 treatment increased forskolin/IBMX (F&I) stimulated short-circuit current (f, 24 and 72 hrs, *P<0.001 and **P<0.01 versus control, Bonferroni post-test). FGF10 treatment did not significantly affect conductance (g, NS, Bonferroni post-test). Graph bars = mean +/− SEM.