Table 3.

Univariable analysis and cox proportional hazards regression analysis

Variable	Univariable analysis			Multivariable analysis
	Hazard ratio	95% CI	P	Hazard ratio	95% CI	P
Age	1.388	1.112–1.733	0.004	1.649	1.306–2.081	<0.001
Gender
Female	R
Male	1.243	0.965–1.601	0.092
Smoking history
N	R
Y	1.426	1.120–1.815	0.004	1.157	0.878–1.524	0.300
pT category
T1–2	R			R		0.007
T3–4	2.030	1.558–2.645	<0.001	1.455	1.097–1.930	0.009
pN category
N0	R		<0.001	R		<0.001
N1	2.414	1.808–3.22	<0.001	2.277	1.690–3.067	<0.001
N2	4.097	3.153–5.323	<0.001	4.233	3.216–5.570	<0.001
N3	6.170	1.953–19.493	0.002	5.121	1.530–17.144	0.008
Histology
Histology ADC	R			R
Histology CC	1.311	1.050–1.636	0.017	0.965	0.744–1.252	0.789
PGTD
PGTD I	R		<0.001	R		0.008
PGTD II	0.174	0.091–0.332	<0.001	2.671	1.433–4.979	0.002
PGTD III	0.789	0.594–1.049	0.103	2.563	1.315–4.999	0.006
Chemotherapy
N	R
Y	1.166	0.934–1.457	0.175
NLR
<3.1	R
>3.1	1.845	1.457–2.337	<0.001	1.648	1.010–2.687	0.045
dNLR
<0.499	R
>0.499	0.627	0.497–0.790	<0.001	1.470	0.936–2.309	0.095
PLR
<170.58	R
>170.58	1.636	1.284–2.085	<0.001	1.201	0.895–1.621	0.221
LMR
<3.53	R
>3.53	0.619	0.496–0.772	<0.001	1.020	0.770–1.351	0.890
SII
<781.82	R
>781.82	1.852	1.463–2.344	<0.001	1.412	0.955–2.090	0.084

pT category pathologcial T category

pN category pathologcial N category

R reference

ADC adenocarcinoma

SCC squamous cell carcinoma

PGTD pathological grading of tumor differentiation

NLR neutrophil to lymphocyte ratio

dNLR derived neutrophil to lymphocyte ratio

PLR platelet to lymphocyte ratio

LMR lymphocyte to monocyte ratio

SII systematic immune-inflammation index