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. Author manuscript; available in PMC: 2018 Jun 27.
Published in final edited form as: Prog Mol Biol Transl Sci. 2014;122:131–167. doi: 10.1016/B978-0-12-420170-5.00005-2

Figure 4. The phosphorylation of 4E-BP by mTORC1 leads to the formation of eIF4F, the cap-dependent translation initiation complex.

Figure 4

The eIF4 group of eIFs form the cap-binding complex eIF4F, which consists of the cap-binding protein eIF4E, the DEAD-box RNA helicase eIF4A, and the scaffolding protein eIF4G. eIF4G circularizes the mRNA by interacting simultaneously with eIF4E and PABPs.