Fig. 2.

Subject and metabolite profiles.

Subjects were subdivided into three groups: group 1, normal estradiol (E2) and normal bone mineral density (BMD) (NN); group 2, low E2 with normal BMD (LN); and group 3, low E2 with low BMD (LL). Metabolites identified were subdivided into three sets: 1, levels differed significantly different NN and LN or between NN and LL groups but were comparable in LN and LL; 2, levels differed significantly between NN and LL, or between LN and LL but were equivalent between NN and LN groups; 3, significantly different levels were seen between NN and LN, LN and LL, and NN and LL groups. S, significant; NS, not significant, N, normal levels. Arrows indicate down-regulation.