Metabolites significantly changed by estrogen deficiency.
Comprehensive metabolomic analysis was performed in sera from NN, LN and LL subjects, and metabolite levels compared between groups. Metabolites showing significant differences between NN and LN or NN and LL groups are shown. (A, cationic; B, anionic). Data represent mean levels of indicated metabolite ± SD (μM; n = 30, 46 and 33 for respective NN, LN and LL subjects; *p < 0.05. **p < 0.01).