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Impact of levobupivacaine (1 mM; 24 h) in relevant microenvironmental tumor bioenergetic conditions. The effect of 1 mM levobupivacaine on DU145 cell proliferation was assessed in (A) 25 mM ‘high’ glucose medium under normoxia and hypoxia, (B) 5 mM ‘low’ glucose medium under normoxia and (C), 5 mM ‘low’ glucose medium under hypoxia. All the data shown correspond to the mean value ± SD of N ≥ 3 different experiments. Significantly different from the untreated cells at: * P ≤ 0.05.
