Table 2.

Estimated changes of the age-standardised incidence rate of Merkel cell carcinoma.

Country	Period for trend analysis	ICD-O 2 or 3 coding since	Population coverage (2005)	Men				Women
			%	Cases	EAPC	95% CI	Δ	Cases	EAPC	95% CI	Δ
US, SEER9-White	1995–2012	1990	8.7	1813	2.2	1.2; 3.3	1.6	1167	2.5	1.3; 3.7	0.9
US, SEER9-Black	1995–2012	1990	8.7	22	0.3	−6.9; 8.1	0.0	29	6.4	−1.8; 15.2	0.3
US, SEER9-Other	1995–2012	1990	18.1	81	−0.1	−3.0; 2.8	0.0	69	2.1	−3.9; 8.5	0.0
New Zealand	1995–2007	1993	100.0	171	2.0	−4.1; 8.5	0.9	172	2.0	−1.6; 5.8	0.7
United Kingdom	1995–2007	1995	74.2	672	6.3	3.0; 9.7	0.8	872	7.9	4.9; 11.0	0.9
Australia	1995–2007	1992	98.8	1006	3.9	1.6; 6.3	2.2	609	2.5	−0.3; 5.3	0.6
Canada	1995–2007	1992	76.3	298	4.9	1.0; 9.0	0.6	282	4.8	0.2; 9.6	0.4
Czech Republic	1995–2007	1994	100.0	62	10.4	4.8; 16.2	0.7	119	6.5	2.6; 10.6	0.5
Denmark	1995–2007	1990	100.0	70	−2.8	−10.0; 5.0	−0.3	90	−3.2	−7.6; 1.5	−0.3
France	1995–2007	1994	9.9	131	9.7	3.5; 16.3	1.9	192	3.5	−2.6; 10.0	0.7
Ireland	1995–2007	1994	100.0	66	3.0	−13.6; 22.7	0.4	100	9.3	2.9; 16.1	1.7
Israel, Jews	1995–2007	1992	79.5	110	7.1	2.0; 12.4	1.9	96	2.4	−6.1; 11.8	0.4
Italy	1996–2007	1996	7.3	89	21.0	8.0; 35.5	2.8	88	6.4	−5.0; 19.2	0.6
Japan	1995–2007	1995	10.1	34	−1.9	−10.1; 7.0	0.0	54	8.9	2.4; 15.9	0.2
Netherlands	1995–2007	1993	100.0	317	8.1	5.0; 11.3	1.6	416	7.1	4.1; 10.2	1.3
Slovakia	2000–2007	2000	100.0	22	5.2	−4.6; 16.1	0.3	38	27.2	−6.6; 73.2	1.0
Spain	1995–2007	1995	8.0	49	6.4	−5.9; 20.2	0.7	48	2.6	−8.6; 15.1	0.2
Sweden	1995–2007	1993	100.0	163	1.0	−3.5; 5.8	0.1	207	0.5	−4.2; 5.5	0.1
Norway	1995–2007	1993	100.0	60	−0.1	−7.2; 7.5	0.0	99	−0.5	−5.4; 4.6	−0.1
Finland	1995–2007	1990	100.0	71	9.4	−1.7; 21.6	1.1	149	1.6	−0.4; 7.3	0.2
Germany	1996–2007	1996	1.3	20	5.5	−11.2; 25.4	0.8	31	10.0	−9.0; 33.0	1.2

The estimated percentage annual change (EAPC) and the estimated rate differences Δ per million person years are derived from log-binomial models; the time periods for these analyses are given in the second column.