Figure 4.

Effects of long‐term diazepam and imidazenil treatment on class 1 HDACs mRNA profiling in frontal cortex. Long‐term diazepam but not imidazenil increased HDAC1 and HDAC2 expression in frontal cortex. Frontal cortices of rats treated with increasing doses of diazepam, imidazenil or vehicle for 10 days were sacrificed 18 hr after the last dose, brains collected and frontal cortices dissected for mRNA analysis. Values are expressed as mean ± SEM of the fold change in controls, n = 5 rats. *P < .05 significantly different from controls, one‐way ANOVA followed by post hoc Turkey's test