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. 2018 Jun 25;18:680. doi: 10.1186/s12885-018-4588-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effect of brusatol and anticancer drugs on the HCV RNA level. a-b qRT-PCRs for HCV RNA in the HPI cells. The value for HCV RNA was normalized by the value for GAPDH RNA and is presented as fold change to that of control. Statistical significance *: p < 0.01, **: p < 0.001, ***: p < 0.0001 versus 0 nM or control. a qRT-PCRs after the administration of brusatol. b qRT-PCRs after the administration of agents at a concentration for the GI50 (80 nM, 4.3 μg/ml, 2.0 μg/ml and 8.0 μM for brusatol, CDDP, MMC and sorafenib, respectively)