Table 5.
Allele and genotype frequencies of SNPs in CP patients with neonatal encephalopathy and controls
| Group | Allele frequency | P | OR (95% CI) | Genotype frequency | P | |||
|---|---|---|---|---|---|---|---|---|
| rs3782219 | C | T | C/C | C/T | T/T | |||
| Case | 300 (0.575) | 222 (0.425) | 0.185 | 0.869 | 82 (0.314) | 136 (0.521) | 43 (0.165) | 0.289 |
| Control | 774 (0.608) | 498 (0.392) | (0.707~ 1.069) | 235 (0.369) | 304 (0.478) | 97 (0.153) | ||
| rs2293054 | A | G | A/A | A/G | G/G | |||
| Case | 122 (0.234) | 400 (0.766) | 0.100 | 1.228 | 15 (0.057) | 92 (0.352) | 154 (0.590) | 0.256 |
| Control | 253 (0.199) | 1019 (0.801) | (0.961~ 1.560) | 26 (0.041) | 201 (0.316) | 409 (0.643) | ||
| rs10774909 | C | G | C/C | C/G | G/G | |||
| Case | 343 (0.657) | 179 (0.343) | 0.364 | 0.905 | 98 (0.375) | 147 (0.563) | 16 (0.061) | 0.001 a |
| Control | 864 (0.679) | 408 (0.321) | (0.729~ 1.123) | 294 (0.462) | 276 (0.434) | 66 (0.104) | ||
| rs3741475 | A | G | A/A | A/G | G/G | |||
| Case | 145 (0.278) | 377 (0.722) | 0.675 | 1.050 | 10 (0.038) | 125 (0.479) | 126 (0.483) | 0.003 b |
| Control | 341 (0.268) | 931 (0.732) | (0.836~ 1.319) | 52 (0.082) | 237 (0.373) | 347 (0.546) | ||
| rs2682826 | A | G | A/A | A/G | G/G | |||
| Case | 145 (0.278) | 377 (0.722) | 0.531 | 1.076 | 9 (0.034) | 127 (0.487) | 125 (0.479) | 0.0005 c |
| Control | 335 (0.263) | 937 (0.737) | (0.856~ 1.352) | 52 (0.082) | 231 (0.363) | 353 (0.555) | ||
aAfter the SNPSpD correction, p = 0.004; bAfter the SNPSpD correction, p = 0.012; cAfter the SNPSpD correction, p = 0.002