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. 2018 Jun 26;16:130. doi: 10.1186/s12955-018-0950-7

Table 4.

MCID estimates for minimally improved patients as indicated on the GRC during follow-up

Measurement period N CAT CAT Standardized CCQ Total CCQ Total Standardized SGRQ Total
15-point GRC T1-T0 196 −3.1*±5.3
(− 3.9 to − 2.4)
− 7.8*±13.2
(− 9.7 to − 5.9)
−0.6*±0.8
(− 0.7 to − 0.4)
− 9.3*±14.0
(− 11.3 to − 7.3)
− 8.4*±11.8
(− 10.1 to − 6.7)
15-point GRC T2-T0 107 −2.7*±6.4
(− 4.0 to − 1.5)
−6.9*±16.1
(− 9.9 to − 3.8)
−0.4*±1.0
(− 0.6 to − 0.2)
− 7.3*±16.8
(− 10.5 to − 4.0)
− 7.6*±13.8
(− 10.2 to − 4.9)
15-point GRC T3-T0 96 − 2.7*±6.7
(− 4.1 to − 1.4)
−6.8*±16.7
(− 10.2 to − 3.5)
−0.4*±1.1
(− 0.6 to − 0.2)
− 7.0*±18.0
(− 10.6 to − 3.3)
− 9.2*±14.0
(− 12.1 to − 6.3)
15-point GRC T4-T0 80 −2.3*±6.1
(− 3.7 to − 1.0)
−5.8*±15.2
(− 9.2 to − 2.4)
−0.5*±0.8
(− 0.7 to − 0.3)
− 7.6*±13.8
(− 10.8 to − 4.7)
− 10.3*±12.9
(− 13.2 to − 7.4)
15-point GRC T5-T0 88 −2.8*±6.7
(− 4.2 to − 1.4)
−7.0*±16.7
(− 10.5 to − 3.5)
− 0.5*±1.0
(− 0.7 to − 0.3)
− 8.3*±16.3
(− 11.7 to − 4.8)
− 8.8*±14.1
(− 11.8 to − 5.8)
Five-point GRC T5-T0 81 −1.4*±5.9
(− 2.7 to − 0.1)
−3.5*±14.7
(− 6.7 to − 0.3)
−0.3*±0.8
(− 0.5 to − 0.2)
− 5.5*±13.8
(− 8.7 to − 2.5)
−7.7*±12.9
(− 10.5 to − 4.8)

Minimal change scores reported as mean ± SD (95%CI). Change is measured compared to baseline. Negative values represent improvement for CAT, CCQ and SGRQ. CAT and CCQ were standardized into a scale from zero to 100 to be comparable with SGRQ

*Significance of change scores p < 0.05 at T1/T2/T3/T4/T5 compared to baseline (T0)

95%CI 95% Confidence Interval, CAT COPD Assessment Test, CCQ Clinical COPD Questionnaire, GRC Global Rating of Change scale, N number of patients, SD Standard Deviation, SGRQ St. George’s Respiratory Questionnaire, T0 Measurement at baseline, T1 Measurement at discharge, T2 3 months follow-up, T3 6 months follow-up, T4 9 months follow-up, T5 12 months follow-up