Table 3.
Impact of listed penicillin allergy on risk of meticillin resistant Staphylococcus aureus (MRSA)and Clostridium difficile
| Outcomes | Penicillin allergy | No penicillin allergy |
|---|---|---|
| MRSA: | ||
| No of patients | 64 141 | 237 258 |
| No of MRSA cases | 442 | 923 |
| Person years | 383 199 | 1 446 753 |
| Hazard ratio (95% CI)* | 1.84 (1.64 to 2.06) | 1.0 (reference) |
| Multivariable adjusted hazard ratio (95% CI)† | 1.69 (1.51 to 1.90) | 1.0 (reference) |
| C difficile: | ||
| No of patients | 64 141 | 237 258 |
| No of C difficile cases | 442 | 1246 |
| Person years | 383 469 | 1 446 658 |
| Hazard ratio (95% CI)* | 1.37 (1.23 to 1.53) | 1.0 (reference) |
| Multivariable adjusted hazard ratio (95% CI)† | 1.26 (1.12 to 1.40) | 1.0 (reference) |
*
Matched on age, sex, and study entry time.
†
Matched on age, sex, study entry time and adjusted for age, sex, body mass index, socioeconomic status, smoking status, alcohol status, Charlson comorbidity index, hemodialysis, antibiotic prescriptions, proton pump inhibitor use, corticosteroid use, other antibiotic allergies, nursing home resident, visits to general practitioner, and admissions to hospital.