Figure 9.

Expression Regulation of PGC-1 α and CAD65 Genes after Increased Expression of the Frataxin Protein in Muscles and Heart Treated Mice with AAV9-plTALE_ST10X

(A–C) The levels of expression of frataxin (A), PGC-1α (B), and GAD65 proteins (C) in the muscles of mice treated with AAV9-pTALE-ST10X-6 + AAV9- plTALE_ST10-8 + AAV9-scFv compared to untreated mice. (D and E) The levels of expression of frataxin and GAD65 (D) and PGC-1α proteins (E) in the heart of mice, which received the same treatment compared to untreated mice. *p < 0.05, **p < 0.003, ***p < 0.0003, and ****p < 0.0001. (A–E) Results are the average ± SEM.