Table II.
Univariate and multivariate Cox proportional hazard analysis of LDHD expression and overall survival for patients with clear cell renal cell carcinoma in the TCGA and FUSCC cohort.
| Univariate (TCGA) | Multivariate (TCGA) | Univariate (FUSCC) | Multivariate (FUSCC) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variables | HR | (95% CI) | P-value | HR | (95% CI) | P-value | HR | (95% CI) | P-value | HR | (95% CI) | P-value |
| Age | 1.028 | (1.015–1.042) | <0.0001 | 1.036 | (1.020–1.053) | <0.0001 | 1.001 | (0.997–1.025) | 0.932 | 0.996 | (0.961–1.034) | 0.858 |
| Sex | 1.073 | (0.781–1.473) | 0.665 | |||||||||
| T | 1.964 | (1.658–2.325) | <0.0001 | |||||||||
| N | 2.799 | (1.486–5.274) | 0.001 | |||||||||
| M | 4.448 | (3.221–6.141) | <0.0001 | |||||||||
| AJCC stage | 1.944 | (1.695–2.229) | <0.0001 | 1.603 | (1.317–1.949) | <0.0001 | 2.065 | (1.597–2.671) | <0.0001 | 2.325 | (1.538–3.514) | <0.0001 |
| Fuhrman grade | 2.350 | (1.899–2.908) | <0.0001 | 1.230 | (0.920–1.644) | 0.162 | 2.007 | (1.309–3.077) | 0.001 | 0.959 | (0.529–1.738) | 0.891 |
| Hb | 0.584 | (0.415–0.823) | 0.002 | 0.915 | (0.624–1.342) | 0.651 | 1.003 | (0.995–1.011) | 0.534 | 1.008 | (0.985–1.032) | 0.493 |
| WBC | 0.652 | (0.471–0.902) | 0.010 | 1.014 | (0.694–1.483) | 0.942 | 0.994 | (0.986–1.002) | 0.142 | 0.985 | (0.972–1.000) | 0.043 |
| PLT | 1.702 | (1.145–2.529) | 0.008 | 1.086 | (0.748–1.579) | 0.664 | 1.004 | (1.000–1.008) | 0.061 | 1.005 | (0.999–1.010) | 0.083 |
| Tumour size | 1.174 | (0.946–1.459) | 0.146 | |||||||||
| Laterality | 0.669 | (0.491–0.913) | 0.011 | 0.664 | (0.467–0.944) | 0.023 | 1.075 | (0.606–1.909) | 0.803 | 1.197 | (0.544–2.635) | 0.655 |
| LDHA | 0.894 | (0.690–1.158) | 0.396 | |||||||||
| LDHAL6B | 1.552 | (1.286–1.874) | <0.0001 | 1.285 | (1.048–1.576) | 0.016 | 1.010 | (0.963–1.059) | 0.680 | 1.066 | (0.994–1.144) | 0.073 |
| LDHAL6A | 0.895 | (0.752–1.065) | 0.212 | |||||||||
| LDHB | 1.087 | (0.813–1.453) | 0.574 | |||||||||
| LDHC | 1.093 | (1.002–1.193) | 0.046 | 1.073 | (0.978–1.177) | 0.137 | ||||||
| LDHD | 0.765 | (0.682–0.858) | <0.0001 | 0.872 | (0.764–0.994) | 0.040 | 0.944 | (0.897–0.994) | 0.029 | 0.899 | (0.826–0.979) | 0.014 |
LDH, lactate dehydrogenase; LDHAL6B, LDH A like 6B; TGCA, The Cancer Genome Atlas; FUSCC, Fudan University Shanghai Cancer Centre; HR, hazard ratio; CI, confidence interval; T, tumor; N, node; M, metastasis; Hb, hemoglobin; WBC, white blood cell; PLT, platelet.