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. 2018 May 16;16(1):931–939. doi: 10.3892/ol.2018.8713

Figure 3.

Figure 3.

KFX prevents ERK phosphorylation-mediated anti-apoptotic and inflammatory responses. SGC-7901 cells were cultured to near (80–90%) confluence and then administrated with 0.5 mg/ml KFX in the presence or absence of 3 nmol/l PMA for 12 h. Immunoblotting assays of (A) p-ERK/ERK; (B) c-caspase-3, Bax/Bcl-2 and p53; (C) IL-6, IL-1β and TNF-α in SGC-7901 cells. The histogram is the quantitative analysis of the corresponding immunoblots and the data are expressed as fold over control group; n=6 for each group. Data are presented as the mean ± standard error of the mean. *P<0.05 compared with control; #P<0.05 compared with PMA. KFX, Kangfuxin; p-ERK, phosphorylated extracellular signal-regulated kinase; c-caspcase-3, cleaved caspase-3; Bcl-2, B-cell lymphoma 2; Bax, Bcl-2 associated X; IL, interleukin; p53, tumor protein p53; TNF, tumor necrosis factor; PMA, phorbol 12-myristate 13-acetate; DMSO, dimethyl sulfoxide; con, control.