Fluid overload is associated with worse clinical outcomes in the retrospective cohort. For individuals with a single recorded admission during the study time frame, cumulative peak fluid overload percent is directly related to (A) hospital length of stay, (B) duration of β-agonist therapy, and (C) duration of supplemental oxygen. The linear regression coefficient (coef), 95% confidence interval (CI), and P value are shown (multivariable analysis adjusted for age, sex, race, body mass index, use of high-dose inhaled corticosteroids, initial serum bicarbonate, season, and acute asthma severity score).