Wnt6 promotes the migration of HCT116 and SW480 cells. The migration of (A) HCT116 and (B) SW480 cells was evaluated using Transwell assays in CON, shNC, shWnt6, EV and shWnt6 groups. **P<0.01 vs. shNC; ##P<0.01 vs. shWnt6. sh, short hairpin; NC, negative control; EV, empty vector; p, plasmid; CON, control.