Fig. 3.

Mefloquine plasma concentrations in BALB/c mice. (A) Animals were treated with 100 mg/kg mefloquine per os twice per week. Plasma concentrations as assessed by HPLC are given for weeks 2, 6 and 12 of treatment. At these intervals, plasma concentrations were measured 6, 24 and 48 h after dosing (n = 3 for each time point). (B) Modeling of mefloquine concentrations as measured in (A) based on a standard two-compartment pharmacokinetic model with first-order adsorption. Predicted values are shown as solid line. Empty circles show observed mefloquine concentrations.