Fig. 4.
Activity of mefloquine and ten derivatives against E. multilocularis metacestodes in vitro. (A) Mefloquine and ten derivatives were assessed by PGI-assay for their in vitro activity against E. multilocularis metacestodes. Assessments of parasite-damage were performed after 5 and 12 days of drug-incubations at 10, 20, 30, and 40 μM in biological triplicates. Lower concentrations are not shown, as below 10 μM no activity was observed for any of the compounds listed. (B) Structural analysis of mefloquine and ten derivatives concerning presence (+) or absence (−) of a trifluoromethyl group (CF3) at position 8 of the quinoline structure (R1) and an amino-group containing residue at position 4 of the quinoline structure (R2).