Table 1.
List of ten mefloquine derivatives and synthesis.
 | ||||
|---|---|---|---|---|
| abbreviation | full name | R1 | R2 | source |
| Mefloquine | (2,8-bis(trifluoromethyl)quinolin-4-yl)-piperidin-2-yl-methanol | -CF3 | -CHOHPip | Selleckchem |
| PASALR-01-095 | ethyl 2-((2,8-bis(trifluoromethyl)quinolin-4-yl)oxy)acetate | -CF3 | -OCH2CO2Et | Acros Organics, according to (Lilienkampf et al., 2009) |
| PAMMLR-01-99.2 | 4-methoxy-2-(trifluoromethyl)quinoline | -H | -OCH3 | 2, Fig. 1 |
| PASALR-01-097 | N1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethane-1,2-diamine | -CF3 | -NHCH2CH2NH2 | (Barbosa-Lima et al., 2017) |
| MEFLOMETIL-02 | 4-methoxy-2,8-bis(trifluoromethyl)quinoline | -CF3 | -OCH3 | (Barbosa-Lima et al., 2017) |
| PASALR-01-137 | 4-ethoxy-2-(trifluoromethyl)quinoline | -H | -OEt | 3, Fig. 1 |
| PASALR-01-146 | N-(2-chloroethyl)-2,8-bis(trifluoromethyl)quinolin-4-amine | -CF3 | -NHCH2CH2Cl | (Barbosa-Lima et al., 2017) |
| PAMMLR-01-102-2 | 2-((2-(trifluoromethyl)quinolin-4-yl)amino)ethanol | -H | -NHCH2CH2OH | 4, Fig. 1 |
| PASALR-01-144 | N-(2-chloroethyl)-2-(trifluoromethyl)quinolin-4-amine | -H | -NHCH2CH2Cl | 5, Fig. 1 |
| PASALR-01-096 | N-butyl-2,8-bis(trifluoromethyl)quinolin-4-amine | -CF3 | -NHbutyl | (Barbosa-Lima et al., 2017) |
| PASALR-01-126 | 2-((2,8-bis(trifluoromethyl)quinolin-4-yl)amino)ethanol | -CF3 | -NHCH2CH2OH | (Barbosa-Lima et al., 2017) |