Table 1.
Demographic and clinical characteristics of all subjects
| dMIG (n = 10) | ndMIG (n = 22) | MDD (n = 13) | HC (n = 27) | P value | |
|---|---|---|---|---|---|
| Age, y, mean (SD) | 27.8 (9.25) | 33.59 (8.07) | 30.92 (9.1) | 29.48 (7,18) | 0.206a |
| Male | 3 (30%) | 5 (22.7%) | 3 (23%) | 10 (37%) | 0.685b |
| Education, y, mean (SD) | 13.6 (3.41) | 19 (3.28) | 13.65 (2.93) | 16.11 (3.02) | 0.531a |
| Clinical characters of migraine | |||||
| With/without aura | 0/10 | 0/22 | NA | NA | |
| Duration of migraine, y, mean (SD) | 7.2 (5.55) | 9.82 (7.14) | NA | NA | 0.314c |
| Attack frequency, per month, mean (SD) | 8.52 (7.02) | 4.5 (3.50) | NA | NA | 0.08c |
| Attack duration, h, mean (SD) | 18.65 (14.39) | 12.75 (16.79) | NA | NA | 0.42c |
| VAS score (0–10), mean (SD) | 6.55 (1.17) | 5.88 (1.31) | NA | NA | 0.174c |
| HIT-6, mean (SD) | 65.1 (6.26) | 60 (5.77) | NA | NA | 0.081c |
| MoCA, mean (SD) | 27.5 (2.88) | 27.82 (1.5) | 27.92 (1.66) | 30.59 (1.83) | 0.620a |
| 24-HRSD, mean (SD) | 26.9 (6.67) | 3 (2.23) | 27.85 (6.49) | 2.48 (2.12) | < 0.001a d |
| 14-HAMA, mean (SD) | 6 (1.826) | 3.82 (2.59) | 5.23 (2.28) | 4.19 (2.69) | 0.088a |
aP value for the age, MoCA and neuropsychological scores distribution in the four groups were obtained using a separate one-way ANCOVA tests. Post-hoc tests were then performed using the t-test
bP value for the gender distribution and sleep disturbance in the four groups were obtained using a chi-squared test
cP value for the clinical characters distribution for dMIG and ndMIG group were obtained using two sample t-test
dPost-hoc paired comparisons showed significant differences between dMIG versus ndMIG and HC, depression versus ndMIG and HC, P < 0.001
dMIG migraine with depression, ndMIG migraine without depression group, MDD major depressive disorder, HC health control group, VAS visual analogue scale, HIT-6 Headache Impact Test, MoCA Montreal Cognitive Assessment, 24-HRSD 24-Hamilton Rating Scale for Depression, 14-HAMA Hamilton Anxiety Rating Scale Values are represented as the mean (standard deviation)