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. 2018 Jun 25;12:74. doi: 10.1186/s13065-018-0442-1

Table 3.

Well-known AchE inhibitors with the respective LD50 in comparison with compound 1

Inhibitors Compound LD50 (mice)
graphic file with name 13065_2018_442_Figb_HTML.gif 1 > 1600 mg/kg
graphic file with name 13065_2018_442_Figc_HTML.gif Donepezil 30 mg/kg [41]
graphic file with name 13065_2018_442_Figd_HTML.gif Physostigmine 3 mg/kg [42]
graphic file with name 13065_2018_442_Fige_HTML.gif Neostigmine  0.54 ± 0.03 mg/kg [1]
graphic file with name 13065_2018_442_Figf_HTML.gif Pyridostigmine 37.5 mg/kg [41]