Table 2.
Antimicrobial activity results of synthesized bis-pyrimidine molecules
| Compound no. | Antimicrobial activity (MIC = µmol/mL) | Fungal species | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Bacterial species | |||||||||
| Gram positive | Gram negative | ||||||||
| S.A. | B.C. | S.T. | P.A. | E.C. | P.R. | A.N. | A.F. a | A.F. b | |
| s1. | 0.16 | 0.08 | – | – | 0.25 | 0.16 | 0.63 | 1.26 | – |
| s2. | 2.36 | 1.18 | – | 2.36 | – | 2.36 | 2.36 | 1.18 | 0.59 |
| s3. | 0.61 | 0.61 | – | – | – | 0.15 | 0.61 | 1.22 | 0.61 |
| s4. | 0.16 | 0.08 | 0.33 | 0.16 | 0.26 | 0.16 | 2.63 | 0.66 | 0.16 |
| s5. | 0.59 | 0.59 | – | – | – | 0.15 | – | 1.18 | 1.18 |
| s6. | – | 0.15 | 2.44 | 1.22 | 0.61 | – | 2.44 | 0.61 | 0.15 |
| s7. | 0.61 | – | 1.22 | 0.61 | 2.44 | 0.08 | – | 1.22 | – |
| s8. | – | 1.23 | 0.31 | 0.15 | 0.61 | – | 2.46 | 0.61 | 0.15 |
| s9. | 0.16 | 0.08 | 0.32 | 0.16 | 0.25 | 0.16 | – | – | 0.32 |
| s10. | 1.27 | 0.63 | 1.27 | 2.54 | – | 0.63 | 0.63 | 1.27 | 0.32 |
| s11. | 0.14 | 0.07 | 0.29 | 1.16 | 0.23 | 0.14 | 0.58 | – | 0.14 |
| s12. | 1.27 | 0.63 | – | 2.54 | – | 0.63 | – | 1.27 | 0.32 |
| s13. | 1.22 | 0.61 | – | – | 1.22 | 0.61 | 1.22 | 1.22 | – |
| s14. | 2.51 | 1.26 | – | 1.26 | – | 2.51 | – | 0.31 | 0.63 |
| s15. | 0.66 | 0.66 | – | – | 0.66 | 0.16 | 0.66 | 0.33 | – |
| s16. | 0.57 | 0.57 | – | – | 0.57 | 0.14 | 2.30 | 0.57 | 0.14 |
| s17. | – | 0.16 | 2.51 | 1.26 | 0.63 | 1.26 | 0.63 | 0.31 | 1.26 |
| s18. | 0.64 | – | 1.28 | 0.64 | 2.56 | 0.08 | 1.28 | – | 0.32 |
| Acetone | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Broth control | NG | NG | NG | NG | NG | NG | NG | NG | NG |
| Std. | 0.34c | 0.34c | 0.68c | 0.68c | 0.34c | 0.68c | 0.82d | 0.82d | 0.82d |
S.A.: Staphylococcus aureus; B.C.: Bacillus cereus; S.T.: Salmonella typhi; P.A.: Pseudomonas aeruginosa; E.C.: Escherichia coli; P.R.: Providencia rettgeri; A.N.: Aspergillus niger
aA.F.: Aspergillus fumigatus; bA.F.: Aspergillus flavus; Resistant (–); NA no activity, NG No growth
Std.: Cefadroxilc; Fluconazoled