Table 2.
Characteristics of the eligible studies
| n | |
|---|---|
| Study design | |
| Observational studies | 58 |
| Intervention studies | 7 |
| Countries of origin | |
| European | 48a |
| USA | 9 |
| Rest of the world | 8 |
| Age groups of subjects | |
| Children (< 14 yrs) only | 24 |
| Children and adolescents (< 19 yrs) only | 15 |
| Adults only | 7 |
| Mixed age group (infants/children, adolescent and adults) | 19 |
| Phentoytpe | |
| Classical PKU only | 26 |
| Classical and moderate PKU | 5 |
| Insufficient details to determine sub-classifications of PKU | 34 |
| Information on dietary control | |
| Information on dietary control providedc | 54 |
| Information on dietary control not provided | 11 |
| Information on phe-free PS | |
| Information on PS providedd | 36 |
| Information on PS not provided | 29 |
Notes: a3 Austria, 1 Czech Republic, 2 France, 9 Germany, 7 Greece, 3 Italy, 2 The Netherlands, 2 Poland, 1 Portugal, 1 Russia, 11 Spain, 1 Switzerland, 3 Turkey and 2 UK.
b3 Japan, 2 Brazil, 1 Australia, 1 China and 1 Lebanon.
cEither details of baseline Phe control at entry provided or the study entry criteria required that patients had to be well-controlled.
dEither information detailing the specific PS used by patients or whether a supplementary source of the nutrients that were the subject of this review were taken by PKU subjects.
Data in bold is highly significant