Table 1: Landmark Trials for Pharmacological Rhythm Control of Atrial Fibrillation in Patients with Heart Failure and Reduced Ejection Fraction.

Study	Publication Year	Sample Size	Treatment Arm (n)	Comparator Arm (n)	Follow-up (months)	Primary Endpoint	Results
DIAMOND-CHF[17]	1999	1,518	Dofetilide (762)	Placebo (756)	36	Death from any cause	No difference in mortality
AF-CHF[18]	2008	1,376	Rhythm control with mainly amiodarone (682)	Rate control (694)	60	Death from cardiovascular causes	No difference for cardiovascular death