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. 2018 Jun 25;18:688. doi: 10.1186/s12885-018-4610-4

Table 3.

Trends in Pancreatic adenocarcinoma Incidence Rates (1973-2014)

	Overall (1973-2014)		Trends
	Overall (1973-2014)		1			2			3
	APC^a (95% CI)	P value^b	year	APC^a (95% CI)	P value^b	year	APC^a (95% CI)	P value^b	year	APC^a (95% CI)	P value^b
Overall	1.03 (0.86-1.21)	<.001	1973-1983	1.84 (0.97-2.71)	<.001	1983-1999	-0.18 (-0.56-0.20)	.35	1999-2014	2.43 (2.11-2.74)	<.001
Sex
Male	0.88 (0.69-1.06)	<.001	1973-1983	1.10 (0.11-2.09)	.03	1983-1999	-0.25 (-0.69-0.20)	0.27	1999-2014	2.33 (1.97-2.69)	<.001
Female	1.16 (0.97-1.36)	<.001	1973-1984	2.49 (1.40-3.59)	<.001	1984-1999	-0.27 (-0.87-0.34)	0.37	1999-2014	2.54 (2.09-3.00)	<.001
Race
White	1.09 (0.91-1.28)	<.001	1973-1983	1.77 (0.84-2.70)	<.001	1983-1999	-014 (-0.55-0.28)	0.50	1999-2014	2.59 (2.24-2.95)	<.001
Black	0.65 (0.43-0.87)	<.001	1973-1986	1.85 (0.31-3.40)	.02	1986-1998	-0.73 (-2.20-0.76)	.32	1998-2014	1.47 (0.76-2.18)	<.001
Others^c	0.89 (0.61-1.18)	<.001	1973-2006	0.26 (-0.09-0.62)	.14	2006-2009	8.41 (-7.86-27.55)	.32	2009-2014	-1.21 (-4.41-2.10)	.46
Age at diagnosis, y
<60	0.38 (0.18-0.59)	<.001	1973-1984	0.91 (-0.16-1.98)	0.09	1984-1993	-2.14 (-3.76- -0.50)	0.01	1993-2014	1.48 (1.16-1.80)	<.001
>60	1.23 (1.05-1.40)	<.001	1973-1984	2.11 (1.32-2.90)	<.001	1984-1999	-0.07 (-0.50-0.36)	0.74	1999-2014	2.58 (2.26-2.91)	<.001
Stage at diagnosis^d
Localized	1.67 (1.03-2.32)	<.001	1973-1981	6.05 (1.61-10.69)	.01	1981-2001	-2.11 (-3.06 - -1.16)	<.001	2001-2014	7.98 (6.63-9.35)	<.001
Regional	1.84 (1.63-2.04)	<.001	1973-2014	1.84 (1.63-2.04)	<.001
Distant	0.95 (0.73-1.18)	<.001	1973-1976	7.56 (-0.44-16.41)	0.06	1976-1995	-0.55 (-0.96- -0.14)	0.01	1995-2014	2.20 (1.90-2.50)	<.001

^aAnnual Percentage Changes, calculated using Joinpoint regression software

^bTwo-sided P value was calculated using t test to determine the significance of APC change

^cIncludes American Indian/Alaskan Native and Asian/Pacific Islander

^dUsing SEER historic stage A