Table 3.
Association of α-internexin protein expression with clinicopathological variables
| Characteristics | N | Reduced/loss of expression (%) | χ2 value | P value |
|---|---|---|---|---|
| GEP-NENs (n = 286) | ||||
| Functional status | 6.213 | 0.013 | ||
| Nonfunctional | 234 | 179(76.5) | ||
| Functional | 52 | 31(59.6) | ||
| Tumor location | 2.356 | 0.308 | ||
| Gastrointestinal tract | 162 | 124(76.5) | 2.340d | 0.126d |
| Rectum | 60 | 32(53.3) | 43.470e | < 0.001e |
| Stomach | 43 | 42(97.7) | ||
| Duodenum | 21 | 17(81.0) | ||
| Esophagus | 18 | 18(100) | ||
| Jejunum/ileum | 9 | 9(100) | ||
| Appendix | 6 | 2(33.3) | ||
| Colon | 5 | 4(80.0) | ||
| Pancreas | 93 | 63(67.7) | ||
| Other | 31 | 23(74.2) | ||
| Tumor gradea | 49.934 | < 0.001 | ||
| G1 | 120 | 69(57.5) | ||
| G2 | 57 | 36(63.2) | ||
| G3 | 101 | 99(98.0) | ||
| Tumor typea | 46.807 | < 0.001 | ||
| NET | 180 | 108(60.0) | ||
| NEC + MANEC | 98 | 96(98.0) | ||
| Tumor stage | 28.106 | < 0.001 | ||
| I + II | 140 | 83(59.3) | ||
| III + IV | 146 | 127(87.0) | ||
| GI-NENs (n = 162) | ||||
| Tumor gradeb | 41.938 | < 0.001 | ||
| G1 | 60 | 31(51.7) | ||
| G2 | 21 | 14(66.7) | ||
| G3 | 75 | 74(98.7) | ||
| Tumor typeb | 40.004 | < 0.001 | ||
| NET | 81 | 45(55.6) | ||
| NEC + MANEC | 75 | 74(98.7) | ||
| Tumor stage | 25.786 | < 0.001 | ||
| I + II | 74 | 43(58.1) | ||
| III + IV | 88 | 81(92.0) | ||
| pNENs (n = 93) | ||||
| Tumor gradec | 2.929 | 0.231 | ||
| G1 | 54 | 34(63.0) | ||
| G2 | 27 | 19(70.4) | ||
| G3 | 10 | 9(90.0) | ||
| Tumor typec | 1.080 | 0.299 | ||
| NET | 84 | 56(66.7) | ||
| NEC + MANEC | 7 | 6(85.7) | ||
| Tumor stage | 4.638 | 0.031 | ||
| I + II | 60 | 36(60.0) | ||
| III + IV | 33 | 27(81.8) | ||
a 278 cases both for tumor grade and tumor type; b 156 cases both for tumor grade and tumor type; c 91cases both for tumor grade and tumor type; d The χ2 and P value were computed by the contrast between gastrointestinal tract and pancreas; e The χ2 and P value were computed by the contrast among different sites of gastrointestinal tract
GEP-NEN: Gastroenteropancreatic neuroendocrine neoplasm; NET: Neuroendocrine tumor; NEC: Neuroendocrine carcinoma; MANEC: Mixed adenoneuroendocrine carcinoma; GI-NEN: Gastrointestinal neuroendocrine neoplasm; pNEN: Pancreatic neuroendocrine neoplasm