Table 4.
Multivariate analysis of overall survival in patients
| Factors | GEP-NENs | GI-NENs | pNENs | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex | 1.403 (0.815–2.414) | 0.222 | 1.261 (0.638–2.493) | 0.505 | 0.443 (0.145–1.350) | 0.152 |
| Age (years) at diagnosis | 1.332 (0.753–2.357) | 0.325 | 1.404 (0.763–2.585) | 0.275 | 0.373 (0.081–1.727) | 0.207 |
| Functional status | 1.048 (0.352–3.120) | 0.932 | 1.300 (0.137–12.375) | 0.820 | 0.657 (0.155–2.789) | 0.569 |
| Tumor location | 0.776 (0.406–1.484) | 0.443 | – | – | – | – |
| Tumor grade | 0.106 (0.017–0.640) | 0.019 | 0.070 (0.013–0.389) | 0.002 | 2.473 (1.164–5.103) | 0.018 |
| Tumor type | 0.468 (0.115–1.903) | 0.289 | 6.531 (2.602–16.392) | < 0.001 | 1.705 (0.233–12.472) | 0.599 |
| Tumor stage | 0.201 (0.083–0.489) | < 0.001 | 3.800 (1.522–9.487) | 0.004 | 21.083 (2.503–177.556) | 0.005 |
| α-internexin expressiona | 0.770 (0.298–1.985) | 0.588 | 1.303 (0.241–7.058) | 0.759 | 3.998 (0.935–17.092) | 0.062 |
aα-internexin expression means reduced/loss of expression of α-internexin
GEP-NEN Gastroenteropancreatic neuroendocrine neoplasm; GI-NEN: Gastrointestinal neuroendocrine neoplasm; pNEN: Pancreatic neuroendocrine neoplasm. HR Hazard ratios, CI Confidence intervals