Table 5.
Correlation of α-internexin methylation status with protein expression (major results)
| Methylation levels, % Median (range) | Z value | P value | ||
|---|---|---|---|---|
| α-internexin (−) | α-internexin (+) | |||
| GEP-NENs (n = 116) | ||||
| Average of total 12 CpG sites | 65.8 (0–85.3) | 64.1 (0–79.5) | 1.692 | 0.091 |
| S4 | 63.3 (0–80.8) | 57.8 (0–73.5) | 2.424 | 0.015 |
| S6 | 66.0 (0–89.3) | 61.0 (0–81.4) | 2.338 | 0.019 |
| GI-NENs (n = 54) | ||||
| Average of total 12 CpG sites | 68.5 (0–81.7) | 61.8 (11.5–67.8) | 2.539 | 0.011 |
| S1 | 53.2 (0–100) | 45.8 (12.6–61.8) | 2.062 | 0.039 |
| S2 | 53.5 (0–68.3) | 41.6 (0–55.3) | 2.855 | 0.004 |
| S3 | 50.0 (0–67.3) | 41.3 (0–52.6) | 2.633 | 0.008 |
| S4 | 64.6 (0–79.5) | 56.7 (0–65.6) | 2.897 | 0.004 |
| S5 | 65.6 (0–85.7) | 62.1 (11.5–76.3) | 2.094 | 0.036 |
| S6 | 67.4 (0–89.3) | 56.0 (0–68.0) | 3.130 | 0.002 |
| S7 | 66.0 (0–85.7) | 61.0 (0–69.4) | 2.105 | 0.035 |
| S8 | 82.9 (0–93.8) | 70.3 (0–84.1) | 2.583 | 0.010 |
| S9 | 66.2 (0–84.4) | 54.9 (0–67.7) | 2.695 | 0.007 |
| S10 | 80.5 (0–93.6) | 65.4 (0–81.6) | 2.606 | 0.009 |
| S11 | 83.2 (0–96.9) | 76.0 (10.8–83.3) | 2.517 | 0.012 |
| S12 | 78.6 (0–88.2) | 66.6 (13.2–79.0) | 2.595 | 0.009 |
| pNENs (n = 49) | ||||
| Average of total 12 CpG sites | 63.6 (49.1–85.3) | 66.0 (24.0–79.5) | 0.164 | 0.870 |
S1, S2...S12 means each CpG site in the region (+ 729~ + 834) of α-internexin
GEP-NEN Gastroenteropancreatic neuroendocrine neoplasm, GI-NEN Gastrointestinal neuroendocrine neoplasm; pNEN: Pancreatic neuroendocrine neoplasm