Table 4.
Best fit multivariate models for the 2492 Asian breast cancer patients treated with breast-conserving therapy (1989–2012)
| Clinicopathologic characteristics | Overall survival | Breast cancer-specific survival | Breast cancer-free interval | Time to local recurrence | ||||
|---|---|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| No. of events/no. of patients | 98/1988 | 54/2120 | 182/1988 | 64/2120 | ||||
| Age at diagnosis | 25.21 [(age/10)−2 − 0.04] + 0.06 [(age/10)2 − 25]a | < 0.001 | 0.95 (0.92–0.98) | 0.001 | 13.14 [(age/10)−2 − 0.04]a | < 0.001 | 0.95 (0.93–0.98) | < 0.001 |
| Tumor size | 1.21 (0.99–1.46) | 0.064 | Not included | 1.15 (1.00–1.32) | 0.050 | Not included | ||
| Grade | < 0.001 | Not included | < 0.001 | Not included | ||||
| 1 | 1 | 1 | ||||||
| 2 | 4.06 (1.59–10.38) | 3.38 (1.78–6.41) | ||||||
| 3 | 4.94 (1.90–12.84) | 4.08 (2.12–7.86) | ||||||
| No. of positive nodes | 1.05 (1.01–1.09) | 0.031 | Not included | 1.06 (1.03–1.09) | 0.001 | Not included | ||
| Histologic subtype | 0.024 | 0.002 | 0.007 | 0.002 | ||||
| Luminal A/B | 1 | 1 | 1 | 1 | ||||
| HER2 enriched | 1.02 (0.50–2.12) | 0.80 (0.24–2.64) | 1.39 (0.85–2.28) | 3.42 (1.82–6.41) | ||||
| Basal | 1.99 (1.22–3.25) | 2.94 (1.64–5.28) | 1.85 (1.27–2.69) | 1.61 (0.82–3.15) | ||||
aWhere age was significantly non-linear, the fractional polynomial function was presented instead of the hazard ratio. Age was scaled by a factor of 10 and centered on 50 years in these models. Where the number of events was insufficient to include all the covariates in the model, only age and histologic subtype were included