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T. pallidum subsp. pallidum Nichols organisms cultured in vitro for 116 days were fully infectious in the rabbit intradermal infection model. This photograph of one of the three rabbits in infectivity experiment A (Table 3) was taken on day 45 postinoculation. Paired sites were inoculated intradermally with the dosages shown. Sites inoculated with higher doses had undergone ulceration, as is typical of intradermal infections in rabbits.
