Table 3.
The KEGG pathway analysis (with P < 0.05) based on the cis- and trans-regulated differentially expressed targets of differentially expressed lncRNAs
| Pathway Id | pathway description | S gene number | TS gene number | B gene number | TB gene number | P value |
|---|---|---|---|---|---|---|
| ko00190 | Oxidative phosphorylation | 74 | 531 | 76 | 689 | 0.000 |
| ko04514 | Cell adhesion molecules (CAMs) | 34 | 531 | 35 | 689 | 0.001 |
| ko00280 | Valine, leucine and isoleucine degradation | 32 | 531 | 33 | 689 | 0.002 |
| ko00240 | Pyrimidine metabolism | 38 | 531 | 40 | 689 | 0.002 |
| ko00620 | Pyruvate metabolism | 30 | 531 | 31 | 689 | 0.003 |
| ko04260 | Cardiac muscle contraction | 22 | 531 | 22 | 689 | 0.003 |
| ko05168 | Herpes simplex infection | 42 | 531 | 45 | 689 | 0.003 |
| ko04210 | Apoptosis | 40 | 531 | 43 | 689 | 0.005 |
| ko00270 | Cysteine and methionine metabolism | 20 | 531 | 20 | 689 | 0.005 |
| ko00020 | Citrate cycle (TCA cycle | 20 | 531 | 20 | 689 | 0.005 |
| ko01200 | Carbon metabolism | 60 | 531 | 67 | 689 | 0.005 |
| ko01230 | Biosynthesis of amino acids | 38 | 531 | 41 | 689 | 0.007 |
| ko04672 | Intestinal immune network for IgA production | 18 | 531 | 18 | 689 | 0.009 |
| ko03010 | Ribosome | 56 | 531 | 63 | 689 | 0.011 |
| ko00640 | Propanoate metabolism | 24 | 531 | 25 | 689 | 0.011 |
| ko00230 | Purine metabolism | 45 | 531 | 50 | 689 | 0.014 |
| ko00970 | Aminoacyl-tRNA biosynthesis | 16 | 531 | 16 | 689 | 0.015 |
| ko03320 | PPAR signaling pathway | 34 | 531 | 37 | 689 | 0.016 |
| ko04217 | Necroptosis | 28 | 531 | 30 | 689 | 0.018 |
| ko01212 | Fatty acid metabolism | 22 | 531 | 23 | 689 | 0.018 |
| ko00630 | Glyoxylate and dicarboxylate metabolism | 22 | 531 | 23 | 689 | 0.018 |
| ko05164 | Influenza A | 38 | 531 | 42 | 689 | 0.020 |
| ko00480 | Glutathione metabolism | 20 | 531 | 21 | 689 | 0.029 |
| ko04216 | Ferroptosis | 12 | 531 | 12 | 689 | 0.043 |
| ko00983 | Drug metabolism - other enzymes | 12 | 531 | 12 | 689 | 0.043 |
S gene number: the number of significant differentially expressed lncRNAs whose cis-or trans- regulated targets match to a KEGG term; TS gene number: the number of significant differentially expressed lncRNAs whose cis- or trans- regulated targets have KEGG annotations; B gene number: the number of detected lncRNAs whose cis- or trans- regulated targets match to a KEGG term; TB gene number: the number of all detected lncRNAs whose cis- or trans- regulated targets have KEGG annotations