Table 3.
Alzheimer’s Disease Biomarker Characteristics
| All (n = 208) | Normal (n = 97) | Mild OSA (n = 76) | Moderate–Severe OSA (n = 35) | |
|---|---|---|---|---|
| CSF Aβ42 baseline (n = 179), mean ± SD | 681.31 ± 236.43 | 681.88 ± 243.18 | 690.61 ± 233.99 | 657.48 ± 224.79 |
| CSF Aβ42 annual change (n = 104), median (IQR) | 29.40 (−9.53 to 71.06) | 40.59 (4.23 to 80.80) | 26.97 (−29.99 to 66.71) | −4.088 (−18.97 to 27.92) |
| CSF P-tau baseline (n = 179), median (IQR) | 41 (31 to 52) | 42.50 (31.5 to 52.05) | 43.55 (30 to 55) | 40.97 (31.71 to 49) |
| CSF P-tau annual change (n = 104), mean ± SD | 1.42 ± 3.93 | 1.35 ± 3.18 | 0.73 ± 4.27 | 3.43 ± 4.90 |
| CSF T-tau baseline (n = 179), median (IQR) | 257.96 (202 to 360.91) | 268.04 (217.65 to 362) | 244.85 (198 to 382) | 248.14 (174 to 343) |
| CSF T-tau annual change (n = 104), mean ± SD | 8.24 ± 21.42 | 7.52 ± 18.86 | 5.85 ± 21.83 | 17.04 ± 27.53 |
| ADPiB PET mask baseline (n = 86), median (IQR) | 1.05 (1.02 to 1.11) | 1.047 (1.02 to 1.09) | 1.061 (1.00 to 1.11) | 1.06 (1.01 to 1.14) |
| ADPiB PET mask annual change (n = 34), median (IQR) | 0.0005 (−0.009 to 0.014) | −0.0020 (−0.0095 to 0.0078) | −0.0022 (−0.0126 to 0.0224) | 0.014 (0.006 to 0.028) |
Definition of abbreviations: Aβ42 = amyloid β42; ADPiB PET mask = Alzheimer’s disease vulnerable regions of interest Pittsburgh compound B PET mask; CSF = cerebrospinal fluid; IQR = interquartile range; OSA = obstructive sleep apnea; PET = positron emission tomography; P-tau = tau phosphorylated at threonine 181; T-tau = total tau.