Table 4.

Final Model Showing Relationship of Annual ΔCSF Aβ₄₂ and Annual ΔPiB with AHIall and AHI4%

Dependent variable	Models	R2	ΔR2	Independent Variables	β	95% CI	P Value
Annual ΔCSF Aβ42	Model	−0.008	0.035	Age	−1.36	−3.67 to 0.95	0.24
				Sex	6.63	−27.72 to 40.99	0.70
				BMI	0.88	−2.36 to 4.12	0.59
				ApoE4	−15.54	−50.69 to 8.81	0.36
	Model + AHI4%*	0.028	0.046	AHI4%	−13.35	−26.06 to −0.64	0.04
	Model	−0.008	0.035	Age	−1.57	−3.86 to 0.70	0.17
				Sex	4.07	−30.36 to 38.51	0.81
				BMI	1.0	−2.27 to 4.27	0.54
				ApoE4	−17.89	−52.58 to 16.79	0.30
	Model + AHIall	0.027	0.044	AHIall	−29.08	−57.08 to −1.08	0.04
Annual ΔPiB	Model	−0.068	0.062	Age	0.001	−0.001 to 0.004	0.28
				Sex	0.001	−0.036 to 0.038	0.96
				BMI	−0.001	−0.004 to 0.002	0.37
				ApoE4	0.01	−0.026 to 0.046	0.36
	Model + AHI4%	0.134	0.072	AHI4%	0.013	−0.004 to 0.03	0.13
	Model	−0.068	0.062	Age	0.001	−0.001 to 0.004	0.25
				Sex	0.001	−0.036 to 0.038	0.96
				BMI	−0.001	−0.004 to 0.002	0.37
				ApoE4	0.01	−0.026 to 0.046	0.56
	Model + AHIall	0.151	0.09	AHIall	0.026	−005 to 0.057	0.09

Definition of abbreviations: Aβ₄₂ = amyloid β₄₂; AHI = apnea–hypopnea index; AHI4% = the sum of all apneas and hypopneas associated with greater that 4% oxygen desaturation; AHIall = the sum of all apneas, hypopneas, or arousals; ApoE4 = apolipoprotein E4; BMI = body mass index; CI = confidence interval; CSF = cerebrospinal fluid; PiB = Pittsburgh compound B.

^*AHI4% is missing in 1 subject owing to errors in home sleep pulse oximetry measurements.