TABLE 3 .
Genes present in significantly different frequencies between case and control patientsa
| Reference genome gene locus tag |
Annotationb | Frequency, no. (%) |
P value | |
|---|---|---|---|---|
| Casec (n = 38) | Controld (n = 76) | |||
| KPK_RS16860, VK055_1478, KP1_RS09340 | Iron ABC transporter permease | 4 (10.5) | 29 (38.1) | 0.004369 |
| KP1_RS12850, KPNJ1_RS13400, KPN_01704 | DeoR family protein/alkaline phosphatase | 32 (84.2) | 43 (56.6) | 0.005060 |
| KPK_RS16855, VK055_1477, KP1_RS09345 | Amino acid ABC transporter substrate-binding protein | 4 (10.5) | 28 (36.8) | 0.005286 |
| KPK_RS16810, VK055_1467, KP1_RS09395e | PTS fructose transporter subunit IIA | 5 (13.1) | 30 (39.4) | 0.006209 |
| KPK_RS16815, VK055_1468, KP1_RS09390 | PTS fructose transporter subunit IIC | 5 (13.1) | 30 (39.4) | 0.006209 |
| KPK_RS16825, VK055_1470, KP1_RS09380 | Formate acetyltransferase | 5 (13.1) | 30 (39.4) | 0.006209 |
| KPK_RS16830, VK055_1471, KP1_RS09375 | Pyruvate formate lyase II Activase | 5 (13.1) | 30 (39.4) | 0.006209 |
| KPK_RS16840, VK055_1473, KP1_RS09365 | Phytanoyl-CoA dioxygenase | 5 (13.1) | 30 (39.4) | 0.006209 |
| KPK_RS16845, VK055_1476, KP1_RS09360 | AraC family transcriptional regulator | 5 (13.1) | 30 (39.4) | 0.006209 |
| KPK_RS16850, VK055_1475, KP1_RS09355 | Membrane protein | 5 (13.1) | 30 (39.4) | 0.006209 |
| KPN_01782 | Deoxygluconate dehydrogenase | 26 (68.4) | 30 (39.4) | 0.007139 |
| KPK_RS16865, VK055_1479, KP1_RS09335 | Iron ABC transporter substrate-binding protein | 5 (13.1) | 30 (39.4) | 0.007219 |
| KPK_RS16820, VK055_1469, KP1_RS09385f | PTS fructose transporter subunit IIB | 6 (15.8) | 32 (42.1) | 0.008326 |
| KPK_RS16835, VK055_1472, KP1_RS09370 | PTS fructose transporter subunit IIB | 6 (15.8) | 32 (42.1) | 0.008326 |
| KP1_RS12840, KPNJ1_RS13410, KPN_01702g | Deoxyribose-phosphate aldolase | 31 (81.5) | 43 (56.6) | 0.009493 |
| KP1_RS12835, KPNJ1_RS13415, KPN_01701 | Alkaline phosphatase/deoR | 31 (81.5) | 43 (56.6) | 0.009493 |
| KP1_RS12830 KPNJ1_RS13420, KPN_01700 | Allulose-6-phosphate 3-epimerase | 31 (81.5) | 43 (56.6) | 0.009493 |
| KP1_RS12825, KPNJ1_RS13425, KPN_01699 | Carbohydrate kinase (ribokinase) | 31 (81.5) | 43 (56.6) | 0.009493 |
| KP1_RS12820, KPNJ1_RS13430, KPN_01698 | Permease | 31 (81.5) | 43 (56.6) | 0.009493 |
| KP1_RS26720, KPK_RS27195h | Tellurium resistance protein TerF | 10 (26.3) | 6 (7.9) | 0.012875 |
| KP1_RS26700, KPK_RS27215 | Tellurium resistance protein TerB | 10 (26.3) | 6 (7.9) | 0.012875 |
| KP1_RS26655, KPK_RS27260 | Tellurium resistance protein TerW | 10 (26.3) | 6 (7.9) | 0.012875 |
| KP1_RS26650, KPK_RS27270 | Tellurium resistance protein TerY | 10 (26.3) | 6 (7.9) | 0.012875 |
| KPNJ1_01715 | Hypothetical protein | 13 (34.2) | 10 (13.2) | 0.013956 |
a
Genes in operons were collapsed into one representative gene. Representative potential protective factors are shown in italic type, and potential risk factors are shown in italic boldface type.
b
PTS, phosphotransferase system; CoA, coenzyme A.
c
Patients with bloodstream infection or pneumonia.
d
Patients with asymptomatic rectal colonization.
e
Representative gene for KPK_RS16810, -16815, -16825, -16830, -16840, -16845, and -16850.
f
Representative gene for KPK_RS16820 and -16835.
g
Representative gene for KP1_RS12820 to -12840.
h
Representative gene for KP1_RS26720, -26700, -26655, and -26650.