Table 1.

Comparison of food, water intake, and body weight (b.wt) change of nondiabetic controls, diabetic controls, and diabetic rats treated with MB, metformin, and insulin during a 5-week study (n = 6 in each group). Values are expressed as mean ± SEM.

Parameter	Treatment	Time (weeks)
		1	2	3	4	5
Food intake (g/100 g)	NC	11.9 ± 3.4	12.2 ± 1.6	12.3 ± 1.7	13.0 ± 0.4	12.9 ± 0.9
	DC	27.6 ± 1.2	25.4 ± 1.4	16.7 ± 0.4	28.0 ± 1.1	24.8 ± 0.3
	MB	10.0 ± 2.1∗	10.2 ± 2.6∗	16.4 ± 1.1	26.47 ± 2.4∗	18.9 ± 0.6
	INS	19.2 ± 2.2∗	18.8 ± 1.9∗	11.2 ± 0.8	15.5 ± 3.0∗	14.2 ± 0.9∗
	MTF	28.2 ± 0.6∗	22.7 ± 0.5	21.8 ± 0.5	19.8 ± 0.7	26.8 ± 1.7
Water intake (mL/100 g)	NC	30 ± 8.2	35 ± 1.4	32.5 ± 8.5	45 ± 9.6	51.2 ± 7.2
	DC	60 ± 9.6	61.3 ± 12.9	95.0 ± 3.7	91.3 ± 3.4	96 ± 1.0
	MB	72.5 ± 2.5	67.0 ± 4.1	73.8 ± 8.3	78.7 ± 9.6	76 ± 1.0
	INS	73.0 ± 4.4	76.3 ± 9.4	76.3 ± 0.1	76.4 ± 4.8	74.2 ± 2.3
	MTF	68.8 ± 3.1	41.3 ± 7.5	45.6 ± 2.5	45.2 ± 2.3	43.8 ± 1.1
% b.wt change/week	NC	44.7 ± 9.4	69.7 ± 5.9	76 ± 8.6	90.7 ± 11.1	92.5 ± 9.9
	DC	−72 ± 8.6	−87.2 ± 20	−77.5 ± 9.8	−77.5 ± 12	−80 ± 7.4
	MB	−13.8 ± 8∗	−11.1 ± 5∗	−19.5 ± 6.2∗	−15.3 ± 6.1∗	−40.5 ± 11
	INS	18.5 ± 13.9∗	3.2 ± 15.7∗	30.0 ± 16.2∗	38.3 ± 18.1∗	28.3 ± 3.2∗
	MTF	−23 ± 7.3	−6 ± 6.8	−32 ± 2.9	−11 ± 17.3	−37 ± 3.2
Glucose (mmol/L)	NC	5.1 ± 0.3	5.1 ± 0.4	4.9 ± 0.3	5.8 ± 0.5	5.3 ± 0.1
	DC	33.1 ± 1.5#	33.1 ± 0#	33.4 ± 0.2#	33.0 ± 0.8#	33.2 ± 0.2#
	MB	27.2 ± 0.3	29.1 ± 0.3	24.2 ± 1.9∗	25.6 ± 0.6∗	26.4 ± 1.0∗
	INS	30.7 ± 0.8	23.2 ± 2.6	21.1 ± 2.3∗	21.9 ± 1.6∗	17.1 ± 0.9∗
	MTF	28.0 ± 2.1	26.0 ± 1.4	25.7 ± 0.5∗	24.6 ± 0.9∗	24.8 ± 0.6∗

^# p < 0.05 by comparison with nondiabetic control and ^∗p < 0.05 by comparison with diabetic control.