Table 4.

Articles included in the review organized in chronological order of publication: authors, animal experiment, study groups, intervention, duration of the experiment, and results.

Reference	Animal	Experiment	Study groups	Intervention	Duration of the experiment	Results
[21]	Albino male rats (Wistar)	Mucosal ulceration left by abrasion with scalpel blade and marker of 8 mm diameter	Group 1. Treated with saline Group 2. Treated with chamomile extract Group 3. Treated with triamcinolone	NC	10 days	Epithelium refurbished absence of inflammation ↑ collagen deposition ↓ apoptosis and TNF-α
[22]	Albino male rats (Wistar)	Injury with 1 mm of depth in the central region of the tongue	Group 1. Chamomile ointment Group 2. Without treatment	Topical application of 2 ml chamomile extract with concentration of 10%	10 days	↑ epithelialization and collagenous fibers ↑ fibroblasts ↓ inflammation
[23]	Female albino rats (Wistar)	Intraperitoneal administration of 5-Fluorouracil	Group 1. Distilled water management Group 2. Chamomile extract	Probe intragastric administration of the alcoholic extract of chamomile	12 days	↓ toxicity caused by medicine ↓ size of the lesion prolonged use caused toxicity in the mucosa of the tongue
[24]	Female albino mice (Swiss)	Application of injection of carrageenan on hind right mouse	Group 1. Saline Group 2. Chamomile	MeOH extract of chamomile	16 days	↓ development of arthritis ↓ histamine ↓ inflammation
[25]	Albino male rats (Wistar)	The animals were trichotomized with an electric razor in an area of skin back approximately 10 cm	Group 1. Ethanolic extract of Chamomile Group 2. Crude extract of Chamomile	Topical application in skin of Wistar rats with carrageenan-induced paw edema	12 days	Not provide anti-inflammatory action on the induced edema
[9]	Male Golden Syrian hamsters	Intraperitoneal administration of 5-Fluorouracil	Group 1. Without treatment Group 2. Chamomile Group 3. Corticosteroids	Ointment with 100 g of chamomile extract	14 days	↑ levels of TNF-α on the 5th day ↓ severity ↓ levels of IL-1β and TNF-α
[26]	Female Syrian Golden hamsters	Intraperitoneal administration of 5-Fluorouracil	Group 1. Without treatment Group 2. Chamomile Group 3. Corticosteroids	Ointment with 100 g of chamomile extract	16 days	↓ incidence of oral mucositis ↓ severity ↓ vascular hyperemia ↓ inflammatory infiltration
[27]	Albino male rats (Wistar)	Intraperitoneal administration of 5-Fluorouracil	Group 1. Without treatment Group 2. Chamomile	Ointment with 10% of chamomile extract	10 days	↑ reepithelialization ↑ collagen fibers ↓ of the inflammatory process ↓ on wound size
[28]	Albino male rats (Wistar)	Traumatic ulcers on tongue with 3 mm diameter	Group 1. Without drugs Group 2. Chamomile Group 3. Acetone of triamcinolone topical	Topical formulation of Chamomile	14 days	↑ healing ↑ repair of the epithelium and connective tissue total in 5 days ↓ inflammatory cells
[29]	Albino male rats (Wistar)	Immersion in boiling water for 8 seconds, resulting in burning of 20% of the body area	Group 1. Without treatment Group 2. Application of olive oil Group 3. Chamomile	Chamomile flowers folder added to olive oil	67 days	↑ tissue regeneration ↓ inflammatory infiltration

UI: uninformed; ↓: reduction; ↑: increase; TNF: tumor necrosis factor; IL: interleukin.