Table 1.
Animal studies using gene therapies for genetic hearing loss model.
| Year | Country | Vector | Gene | Animal | Reference |
|---|---|---|---|---|---|
| 2012 | US | AAV | VGLUT3 | mouse (premature) |
Akil et al. |
| 2014 | US | AAV | Gjb2 | mouse (mature) |
Yu et al. |
| 2015 | Japan | AAV | Gjb2 | mouse (mature and premature) |
Iizuka et al. |
| 2015 | US | AAV | TMC1 | mouse (premature) |
Askew et al. |
| 2016 | South Korea | AAV | MsrB3 | mouse (in utero) |
Kim et al. |
| 2017 | US | AAV | USH3 | mouse (premature) |
Geng et al. |
| 2017 | US | AAV | USH1C | Mouse (premature) |
Pan et al. |
AAV: adenoassociated virus; VGLUT3: vesicular glutamate transporter 3; MsrB3: methionine sulfoxide reductase B3; TMC1: transmembrane channel like 1; USH3: Usher syndrome type III; USH1C: Usher syndrome type Ic.