Table 2.
Animal studies using gene therapies for hearing loss protection (or hearing preservation).
| Year | Country | Vector | Ototoxic insults | Gene | Animal | Reference |
|---|---|---|---|---|---|---|
| 1999 | US | Adv | Aminoglycoside | GDNF | Guinea pig | Yagi et al. |
| 2004 | US | Adv | Aminoglycoside | SOD1 | Guinea pig | Kawamoto et al. |
| 2006 | US | AAV | Cisplatin | XIAP | rat | Cooper et al. |
| 2008 | Japan/China | AAV | Aminoglycoside | GDNF | rat | Liu et al. |
| 2008 | US | siRNA | Cisplatin | TRPV1 and NOx3 | rat | Mukherjea et al. |
| 2009 | US | AAV | Aminoglycoside | Bcl2 | mouse (mature) |
Pfannenstiel et al. |
| 2010 | Australia | Adv | Aminoglycoside | (NT3 and BDNF) | Guinea pig | Wise et al. |
| 2015 | US | Adv | Aminoglycoside | Hsp70 | Guinea pig | Takada et al. |
| 2016 | China | AAV | Cisplatin | XIAP | mouse (mature) |
Jie et al. |
| 2016 | US | siRNA | Acoustic overexposure | AMPK | Mouse (mature) |
Hill et al. |
Adv: adenovirus; AAV: adenoassociated virus; GDNF: glial cell derived neurotrophic factor; SOD: superoxide dismutase; XIAP: X-linked inhibitor of apoptosis; TRPV1: Transient Receptor Potential Cation Channel Subfamily V Member 1; NOx3: NADPH Oxidase 3; NT3: neurotrophin 3; BDNF: brain derived neurotrophic factor; Hsp70: heat shock protein 70; AMPK: AMP-activated protein kinase.