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. Author manuscript; available in PMC: 2018 Jun 27.
Published in final edited form as: Gynecol Oncol. 2017 Jan 7;144(3):613–620. doi: 10.1016/j.ygyno.2017.01.009

Figure 3. HDAC inhibitors, in combination with cisplatin, potently inhibit the homology directed repair of DNA double strand breaks.

Figure 3

A. HeLa-DR cells, which have stably integrated a DNA for measuring HDR activity, were treated with cisplatin and TSA at the indicated concentrations. HDR activity was measured as the percentage of cells that convert to GFP positive, and results were normalized relative to the sample without drug added. Statistical analysis compared each data point with the indicated drug to the results in the absence of added drug; the student’s two-tailed t-test was used, and asterisks represent *, p < 0.05; **, p < 0.01; ***, p < 0.001. B. HeLa-DR cells were tested as in panel A using the HDAC inhibitor SAHA. Statistical tests were done as in Panel A; for the results in the presence of 2.0 µM SAHA, all three curves had p < 0.001.